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| Registros recuperados: 19 | |
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| Silva-Sena,Geralda Gillian; Camporez,Daniela; Santos,Lígia Ramos dos; Silva,Aline Sesana da; Sagrillo Pimassoni,Lúcia Helena; Tieppo,Alessandra; Pimentel Batitucci,Maria do Carmo; Morelato,Renato Lírio; Paula,Flavia de. |
| Abstract Human longevity is a polygenic and multifactorial trait. Pathways related to lifespan are complex and involve molecular, cellular, and environmental processes. In this analytical observational study, we evaluated the relationship between environment factors, oxidative stress status, DNA integrity level, and the association of FOXO3 (rs2802292), SOD2 (rs4880), APOE (rs429358 and rs7412), and SIRT1 (rs2273773) polymorphisms with longevity in oldest-old individuals from southeastern Brazil. We found an association between the FOXO3 GG genotype and gender. While lifestyle, anthropometric, and biochemical characteristics showed significant results, DNA damage and oxidative stress were not related to lifespan. We found that long-lived individuals with... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Lifespan; SNPs; Environmental factors; Oxidative stress; Genomic damage. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572018000300386 |
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| Marrube,G; Soria,LA; Rozen,FMB; Corva,PM; Schor,A; Melucci,LM; Villarreal,EL; Mezzadra,CA; Miquel,MC. |
| La enzima Acido Graso Sintasa (FASN) cataliza la síntesis de los ácidos grasos en la célula y presenta un rol fundamental en el metabolismo de los lípidos. Con el propósito de analizar el efecto de dos polimorfismos de un solo nucleótido (SNPs) en el gen FASN (G>C en el exón 1 y A>G en el exón 34) se analizaron los siguientes caracteres productivos: Peso Vivo Final, Ganancia Diaria de Peso Vivo, Tasa Mensual de Engrasamiento, Grasa Riñonada, Porcentaje de Grasa Riñonada, Rendimiento de la Canal, Porcentaje de Grasa Intramuscular, en novillos de razas Angus (n = 20) y Brangus (n = 60). Se desarrollaron técnicas de mismatch PCR para determinar los genotipos de ambos SNPs. El análisis estadístico se realizó mediante un modelo de efectos fijos... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Bovinos para carne; Calidad de la carne; Gen FASN; SNPs. |
| Ano: 2010 |
URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S1852-62332010000100005 |
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| Almeida,Sabrina Esteves Matos; Almeida,Erik Amazonas de; Terra,Gustavo; Neves,Jairo Pereira; Gonçalves,Paulo Bayard Dias; Weimer,Tania de Azevedo. |
| Three short tandem repeats (STRs), BMS1074, BM1500, IDVGA-51, and three single nucleotide polymorphisms (SNPs), LEPSau3AI (A/B), LEPSau3AI (+/-) and LEPKpn2I linked to the LEP gene were investigated to verify associations with productive performance in postpartum cows of two beef cattle breeds, Aberdeen Angus (AA, n=98) and Charolais (C, n=83). After polymerase chain reaction, STRs were analyzed by vertical electrophoresis and SNPs in agarose gel after endonucleases cleavage. In AA herd 79% of BMS1074*151 carriers had a lower average daily weight gain (ADG) when compared with the population mean daily weight gain (103g), while 62% of BMS1074*151 non-carriers presented a higher ADG (P<0.01); AA animals with at least one BMS1074*151 allele showed a ADG... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Leptin; STRs; SNPs; Beef cattle; Weight gain; Post-partum. |
| Ano: 2007 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782007000100033 |
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| Wang,Jinjin; Zhang,Jianfeng; Li,Linlin; Wang,Yan; Wang,Qian; Zhai,Yujia; You,Haifei; Hu,Dongsheng. |
| Our objective was to evaluate the association of rs12255372 in theTCF7L2 gene with type 2 diabetes mellitus (T2DM) in the world population. We carried out a survey of the literature about the effect of rs12255372 on genetic susceptibility to T2DM by consulting PubMed, the Cochrane Library, and Embase from 2006 to 2012, and then performed a meta-analysis of all the studies in order to evaluate the association between rs12255372 and T2DM. A total of 33 articles including 42 studies (with 34,076 cases and 36,192 controls) were confirmed to be eligible and were included in the final meta-analysis: 6 studies conducted on Europeans, 14 on Caucasians, 17 on Asians, 2 on Africans, and 3 on Americans. Overall, the effect size was as follows: for the variant allele... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Type 2 diabetes mellitus; Rs12255372; SNPs; Meta-analysis. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000400382 |
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| Shaheen,Tayyaba; Zafar,Yusuf; Mehboob-ur-Rahman,. |
| Exploring genetic variation in Gossypium arboreum L. germplasm is useful as it contains many important genes conferring resistance to different stresses. In limited earlier studies, low level of genetic diversity was found by using conventional DNA marker systems which may impede future genome mapping studies. In the present investigation, we explored the extent of Single Nucleotide Polymorphisms (SNP) among 30 conserved regions of Expressed Sequence Tags (EST) of low copy genes between two genotypes of G. arboreum. A total of 27 SNPs including 21 substitutions and 6 Insertions and deletions (Indels) in 7804 bp were found between these genotypes with a frequency of one SNP per 371 bp and one Indel after every 1300 bp. Out of these SNPs, 52% were... |
| Tipo: Journal article |
Palavras-chave: Conserved regions; Gossypium arboretum; SNPs. |
| Ano: 2010 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582010000500003 |
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| Sauvage, Christopher; Lapegue, Sylvie; Bierne, Nicolas; Boudry, Pierre. |
| Summer mortalities of the Pacific cupped oyster Crassostrea gigas have been described in the literature for decades. One solution to overcome this problem would be to select animals more tolerant to summer mortalities, as this trait was shown to be highly heritable (Degrémont, 2003). The identification of markers associated to the resistance would allow to better understand this complex phenomenon and, eventually to establish markers assisted selection. Recently, two moderately dense genetic linkage maps have been established in the Pacific oyster based on microsatellites and AFLP markers (Hubert and Hedgecock, 2004; Li and Guo, 2004). In this context, the development and mapping of SNPs will increase the density of the linkage map and consequently the... |
| Tipo: Text |
Palavras-chave: QTLs analyses; Summer mortaliy; Genetic; SNPs; Crassostrea gigas; Oyster. |
| Ano: 2006 |
URL: http://archimer.ifremer.fr/doc/2006/acte-3351.pdf |
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| Yang,Xiuqin; Li,Haitao; Guan,Qingzhi; Liu,Di. |
| The Toll-like receptor 5 (TLR5) recognizes flagellin of Gram-positive and -negative bacteria and plays an important role in the host defense system. Here, we surveyed single nucleotide polymorphisms (SNPs) in the coding sequence of the porcine TLR5 gene in 83 individuals from five pig breeds, these including Chinese local populations and Western commercial pig breeds. A total of 19 medium polymorphic SNPs (0.25 < PIC < 0.5) were identified, three of which were missense mutations that clustered within the extracellular domain of TLR5. One of the non-synonymous SNPs fell within a 228-amino acid region which has been shown to be important for flagellin recognition. Four SNPs were only found with high frequencies in Oriental pig breeds. The 19 SNPs were... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Porcine; TLR5; SNPs; Haplotype. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572013000100006 |
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| Berenguer,Anabela Gonçalves; Fernandes,Ana Teresa; Oliveira,Susana; Rodrigues,Mariana; Ornelas,Pedro; Romeira,Diogo; Serrão,Tânia; Rosa,Alexandra; Câmara,Rita. |
| BACKGROUND: Asthma is a complex disease influenced by multiple genetic and environmental factors. While Madeira has the highest prevalence of asthma in Portugal (14.6%), the effect of both genetic and environmental factors in this population has never been assessed. We categorized 98 asthma patients according to the Global Initiative for Asthma (GINA) guidelines, established their sensitization profile, and measured their forced expiratory volume in 1second (FEV1) and forced vital capacity (FVC) indexes. Selected single nucleotide polymorphisms (SNPs) were analysed as potential markers for asthma susceptibility and severity in the interleukin 4 (IL4), interleukin 13 (IL13), beta-2-adrenergic receptor (ADRB2), a disintegrin and metalloprotease 33 (ADAM33),... |
| Tipo: Journal article |
Palavras-chave: Asthma; Madeira; SNPs; Susceptibility; Severity. |
| Ano: 2014 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100040 |
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| López Soto,Eduardo Javier; Catanesi,Cecilia Inés. |
| Several single nucleotide polymorphisms (SNPs) in the Mu Opioid Receptor gene (OPRM1) have been identified and associated with a wide variety of clinical phenotypes related both to pain sensitivity and analgesic requirements. The A118G and other potentially functional OPRM1 SNPs show significant differences in their allele distributions among populations. However, they have not been properly addressed in a population genetic analysis. Population stratification could lead to erroneous conclusions when they are not taken into account in association studies. The aim of our study was to analyze OPRM1 SNP variability by comparing population samples of the International Hap Map database and to analyze a new population sample from the city of Corrientes,... |
| Tipo: Info:eu-repo/semantics/report |
Palavras-chave: OPRM1; SNPs; A118G; AMOVA; Population genetics. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572015000200152 |
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| Bassi,Denis; Briñez,Boris; Rosa,Juliana Santa; Oblessuc,Paula Rodrigues; Almeida,Caléo Panhoca de; Nucci,Stella Maris; Silva,Larissa Chariel Domingos da; Chiorato,Alisson Fernando; Vianello,Rosana Pereira; Camargo,Luis Eduardo Aranha; Blair,Matthew Wohlgemuth; Benchimol-Reis,Luciana Lasry. |
| Abstract Angular leaf spot (ALS) and powdery mildew (PWM) are two important fungi diseases causing significant yield losses in common beans. In this study, a new genetic linkage map was constructed using single sequence repeats (SSRs) and single nucleotide polymorphisms (SNPs), in a segregating population derived from the AND 277 x SEA 5 cross, with 105 recombinant inbred lines. Phenotypic evaluations were performed in the greenhouse to identify quantitative trait loci (QTLs) associated with resistance by means of the composite interval mapping analysis. Four QTLs were identified for ALS resistance. The QTL ALS11AS, linked on the SNP BAR 5054, mapped on chromosome Pv11, showed the greatest effect (R2 = 26.5%) on ALS phenotypic variance. For PWM resistance,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Pseudocercospora griseola; Erysiphe polygoni; Quantitative inheritance; SSRs; SNPs. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572017000100109 |
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| Rohfritsch, Audrey; Bierne, Nicolas; Boudry, Pierre; Heurtebise, Serge; Cornette, Florence; Lapegue, Sylvie. |
| Crassostrea gigas originated from the Pacific coast of Asia, but was introduced into several European countries in the early 1970s. Natural populations have now spread across the length of the western seaboard of Europe. To elucidate the demographic and selective processes at play during this rapid expansion, genome-scan analysis was performed on different populations. High diversities and low differentiation were observed overall, but significant genetic differentiation was found among newly established populations and between the newly established northern group and a nearly panmictic group composed of southern European populations and a population from Japan. Loss of genetic diversity was also seen in the north, likely caused by founder events during... |
| Tipo: Text |
Palavras-chave: AFLPs; Crassostrea gigas; Genome scan; Invasive species; Microsatellites; SNPs. |
| Ano: 2013 |
URL: http://archimer.ifremer.fr/doc/00149/25977/24070.pdf |
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| SOTO SEDANO,Johana; MORA MORENO,Rubén Eduardo; CALLE,Fernando; LÓPEZ CARRASCAL,Camilo Ernesto. |
| Cassava, Manihot esculenta Crantz, represents the main food source for more than one billion people. Cassava's production is affected by several diseases, one of the most serious is cassava bacterial blight (CBB) caused by Xanthomonas axonopodis pv. manihotis (Xam). A quantitative trait loci (QTL) analysis for CBB resistance was performed under natural infection conditions, using a mapping population of 99 full-sibs genotypes highly segregant and a SNP-based high dense genetic map. The phenotypic evaluation was carried out in Puerto López, Meta, Colombia, during the rainy season in 2015. Both resistant and susceptible transgressive segregants were detected in the mapping population. Through a non-parametric interval mapping analysis, two QTL were detected,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Cassava; Molecular marker; QTL; Resistance; SNPs; Xanthomonas axonopodis pv. manihotis. |
| Ano: 2017 |
URL: http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0120-548X2017000100002 |
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| Rebelato,Arnaldo Basso; Caetano,Alexandre Rodrigues. |
| Abstract: Runs of homozygosity (ROHs) are long stretches of homozygous genomic segments, identifiable by molecular markers, which can provide genomic information for accurate estimates to characterize populations, determine evolutionary history and demographic information, estimate levels of consanguinity, and identify selection signatures in production animals. This review paper aims to perform a survey of the works on the efficiency of ROHs for these purposes. Factors such as genetic drift, natural or artificial selection, founder effect, and effective population size directly influence the size and distribution of ROHs along the genome. Individually, genome estimates of consanguinity based on ROHs can be obtained using the FROH index, which is generally... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Autozygosity; FROH; Genotyping; Selection signatures; Single nucleotide polymorphism; SNPs. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-204X2018000900975 |
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| Kong,FL; Chen,SY; Ran,JS; Yang,CW; Jiang,XS; Lan,D; Hu,YD; Liu,YP. |
| ABSTRACT A complete linkage disequilibrium between the SNP (SNP B) in BCDO2 gene and the yellow skin phenotype in European domestic chicken has been reported. Here, we genotyped the reported SNPs (SNP A, SNP B, and SNP C) of the BCDO2 gene in 183 Chinese Indigenous chickens from 11 breeds/populations, including 57 yellow, 17 white, and 109 black skin chickens. The frequency of all three SNPs were significantly different between yellow and white skin chickens (p<0.01). In black skin chickens, a high frequency of the heterozygous genotype (AG) in SNP A (0.51) and SNP B (0.48) was observed. A total of three haplotypes (AAA, AGA, and GAA) from these three SNPs were obtained. Frequencies of the proposed yellow skin-associated haplotype AGA in yellow skin,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: B-carotene dioxygenase (BCDO2); Chinese indigenous chickens; SNPs; Skin color. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-635X2017000300393 |
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| Silva,Ronaldo Celerino da; Alves,Neyla Maria Pereira; Pereira,Jorge José de Souza; Coelho,Antonio Victor Campos; Arraes,Luiz Cláudio; Brandão,Lucas André Cavalcanti; Crovella,Sergio; Silva,Jaqueline de Azevêdo. |
| Abstract Vitamin D exerts an immuno-modulatory activity on several immune system cells through the vitamin D receptor (VDR). Herein, we verified that age and a therapeutic regimen containing protease inhibitors are associated with failures in antiretroviral therapies (ARVs). In addition, we assessed whether a VDR SNP (rs11568820: C allele and CC genotype) and GC (rs2228570-rs11568820) allelic combinations are associated with immunological failure (p < 0.05). Our findings suggest a possible role of VDR SNPs on immunological failure in HIV-1+ individuals undergoing regular ARVs. |
| Tipo: Info:eu-repo/semantics/other |
Palavras-chave: VDR; HIV-1; ARVs; SNPs; CD4 recovery. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572019000300351 |
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| Registros recuperados: 19 | |
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